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alendronate sodium

Apo-Alendronate (CA), Co Alendronate (CA), Dom-Alendronate (CA), Fosamax, Gen-Alendronate (CA), Ratio-Alendronate (CA), Sandoz Alendronate

Pharmacologic class: Bisphosphonate

Therapeutic class: Bone-resorption inhibitor

Pregnancy risk category C


乐动体育开户Impedes bone resorption by inhibiting osteoclast activity, absorbing calcium phosphate crystal in bone, and directly blocking dissolution of hydroxyapatite crystal of bone


Tablets: 5 mg, 10 mg, 35 mg, 40 mg, 70 mg

Indications and dosages

乐动体育开户 Paget's disease of bone (men and women)

Adults: 40 mg P.O. daily for 6 months

乐动体育开户 Prevention of osteoporosis in postmenopausal women

Adults: 5 mg P.O. daily or 35 mg P.O. once weekly for up to 7 years

乐动体育开户 Glucocorticoid-induced osteoporosis in men and women

Adults: 5 mg P.O. daily. For postmenopausal women not receiving estrogen, recommended dosage is 10 mg P.O. once daily.

Treatment of osteoporosis in postmenopausal women; treatment to increase bone mass in men with osteoporosis

Adults: 70-mg tablet or 70 mg oral solution P.O. weekly or 10-mg tablet P.O. daily


• Hypersensitivity to drug or its components

• Hypocalcemia

• Esophageal abnormalities such as stricture or achalasia that delay esophageal emptying

• Inability to stand or sit upright for 30 minutes

乐动体育开户• Increased risk of aspiration (oral solution)


Use cautiously in:

乐动体育开户• Severe renal insufficiency (creatinine clearance less than 35 ml/minute), esophageal disease, GI ulcers, gastritis, osteonecrosis of jaw

• pregnant or breastfeeding patients

乐动体育开户• children.


乐动体育开户• Give with 6 to 8 oz of water 30 minutes before first food, beverage, or medication of day.

• Don't give at bedtime or before patient arises for the day.

• Don't give food, other beverages, or oral drugs for at least 30 minutes after giving tablets.

• Keep patient upright for at least 30 minutes after giving dose to avoid serious esophageal irritation.

• Follow oral solution with at least 60 ml (2 oz) of water to facilitate gastric emptying.

乐动体育开户• Be aware that patients should receive supplemental calcium and vitamin D if dietary intake is inadequate.

乐动体育开户• Be aware that aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) may worsen GI upset. Discuss alternative analgesics with prescriber.

Adverse reactions

CNS: headache

CV: hypertension

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, acid regurgitation, esophageal ulcer, flatulence, dyspepsia, abdominal distention, dysphagia

GU:乐动体育开户 urinary tract infection

Hematologic: anemia

Metabolic: hypomagnesemia, hypophosphatemia, hypokalemia, fluid overload

Musculoskeletal: bone or muscle pain

Skin: rash, redness, photosensitivity

Other: abnormal taste


Drug-drug. Antacids, calcium supplements: decreased alendronate absorption

NSAIDs, salicylates: increased risk of GI upset

Ranitidine:乐动体育开户 increased alendronate effect

Drug-diagnostic tests. Calcium, phosphate:乐动体育开户 decreased levels

Drug-food. Any food, caffeine (as in coffee, tea, cocoa), mineral water, orange juice: decreased drug absorption

Patient monitoring

• Monitor for signs and symptoms of GI irritation, including ulcers.

• Monitor blood pressure.

乐动体育开户• Evaluate blood calcium and phosphate levels.

Patient teaching

Tell patient to immediately report serious vomiting, severe chest or abdominal pain, difficulty swallowing, or abdominal swelling.

乐动体育开户• Instruct patient to take tablets first thing in the morning on an empty stomach, with 6 to 8 oz of water only.

乐动体育开户• Instruct patient to follow oral solution with at least 60 ml (2 oz) of water.

• Tell patient not to lie down, eat, drink, or take other oral medications for 30 minutes after taking dose.

乐动体育开户• Advise patient to take only those pain relievers suggested by prescriber. Inform him that some over-the-counter pain medications (such as aspirin and NSAIDs) may worsen drug's adverse effects.

乐动体育开户• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.


A trademark for the drug alendronate sodium.


A biphosphonate used to treat postmenopausal osteoporosis and Paget’s disease of bone. Alendronate reduces vertebral fractures by 48% and other fractures by 21%, increases bone density by 9% and density of the hip bones by 6% over 3 years of therapy.

Adverse effects
Nausea, stomach pain, constipation, diarrhoea, bloating, headaches, dizziness, swelling of joints (especially of hands and feet).

Mechanism of action
Marked inhibition of bone resorption by inhibiting osteoclastic activity and number of osteoclasts by reducing recruitment, and increasing apoptosis.


Alendronate, see there.


A brand name for ALENDRONATE.
References in periodicals archive ?
Although the ADA says that the risk of getting BON from Fosamax is low, dentists have noticed an increase in cases since 2003.
Although the initial study showed significantly less osteoporotic fracture incidence in the treatment group (10.6%) compared with the placebo group (21.0%), the extension trial did not: continuous Fosamax treatment had a fracture incidence of 17.7% compared with 16.9% for those who were switched to placebo.
We remain confident in the efficacy and safety profile of Fosamax, which was developed and studied carefully by dedicated Merck scientists."
Having a hip fracture as a result of medication can happen at an inordinately young age in people whose doctors prescribed Fosamax," states NY defective prescription drug attorney, Rudy Migliore.
Merck (the manufacturer of Fosamax) tried to hide the fact that Fosamax is causing jawbone death!
Plaintiffs in the other Fosamax cases make similar assertions, claiming the drug causes death of the jaw bone, also known as osteonerosis.
The manufacturers of alendronate (Fosamax and Fosamax plus D, by Merck & Co.), ibandronate (Boniva, by Roche Laboratories), risedronate (Actonel and Actonel with calcium, by Procter & Gamble Pharmaceuticals), and zoledronic acid (Reclast and Zometa, by Novartis) included data from men and women treated with each of those drugs.
Women who take Fosamax to reduce their future risk of osteoporosis be warned: you are at increased risk for atrial fibrillation, a heart condition that increases strokes.
Our options seem to be Liquid Fosamax (for G-tube) or the new once a year IV drug Reclast.
For example, Alendronate, a generic version of Fosamax, an osteoporosis medication, is now available from Wal-Mart, Sam's Club and Neighborhood Market outlets for $9 for a 30-day supply or $24 for a 90-day supply.
Thousands of British women take Fosamax for the bone-thinning disease which is a common side effect of the menopause.
from Sandusky, Ohio: Generic verions of Altace, Fosamax, Zetia, and Avandia are not currently available.